Article Details


Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome

[ Vol. 18 , Issue. 3 ]

Author(s):

John M. Yavorski, Rebecca J. Stoll, Mohammad D. Samy, James A. Mauro and George Blanck   Pages 287 - 297 ( 11 )

Abstract:


Background: Relatively little cancer genome atlas data has been associated with clinically relevant stratifications of individual cancers.

Results: Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma, including a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001).

Conclusion: Roles for CAPCR mutations in cancer progression raise a question about the potential dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein structures.

Keywords:

Cytoskeletal and cell-adhesion genomics, Cancer genome atlas, Extra-cellular matrix, Melanoma stratification, Melanoma metastasis.

Affiliation:

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, Department of Molecular Medicine, Morsani College of Medicine, University of South Florida

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