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Recent Advances in Substrate Identification of Protein Kinases in Plants and Their Role in Stress Management

[ Vol. 18 , Issue. 6 ]

Author(s):

Saroj K. Jha, Shikha Malik, Manisha Sharma, Amita Pandey and Girdhar K. Pandey*   Pages 523 - 541 ( 19 )

Abstract:


Protein phosphorylation-dephosphorylation is a well-known regulatory mechanism in biological systems and has become one of the significant means of protein function regulation, modulating most of the biological processes. Protein kinases play vital role in numerous cellular processes. Kinases transduce external signal into responses such as growth, immunity and stress tolerance through phosphorylation of their target proteins. In order to understand these cellular processes at the molecular level, one needs to be aware of the different substrates targeted by protein kinases. Advancement in tools and techniques has bestowed practice of multiple approaches that enable target identification of kinases. However, so far none of the methodologies has been proved to be as good as a panacea for the substrate identification. In this review, the recent advances that have been made in the identifications of putative substrates and the implications of these kinases and their substrates in stress management are discussed.

Keywords:

Kinase, Post-translational modification, Phosphorylation, Signal transduction, Substrate identification, Stress management.

Affiliation:

Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi-110021, Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi-110021, Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi-110021, Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi-110021

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