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Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population

[ Vol. 19 , Issue. 5 ]

Author(s):

Naseem Akhter, Sajad A. Dar, Shilpi Chattopadhyay, Shafiul Haque, Razique Anwer, Mohd Wahid, Arshad Jawed, Mohtashim Lohani, Raju K. Mandal, N. K. Shukla, Yasir Abdul and Syed Akhtar Husain*   Pages 395 - 410 ( 16 )

Abstract:


Background: Genetic changes in p53 gene contribute to breast cancer susceptibility.

Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women.

Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence.

Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

Keywords:

p53 codon72 SNP, Breast cancer, Indian populations, Case-control, Meta-analysis, p53 Arg72Pro polymorphism.

Affiliation:

Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi- 110025, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi- 110025, Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi- 110025, Department of Anatomy, College of Medicine, Al Imam Mohammad Ibn Saud Islamic University, Riyadh, Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi- 110025, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Department of Surgical Oncology, All India Institute of Medical, Sciences, New Delhi 110029, Department of Physiology, Augusta University, Augusta, GA 30912, Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia (A Central University), New Delhi- 110025

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