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Molecular Insights into Muscle Homeostasis, Atrophy and Wasting

[ Vol. 19 , Issue. 5 ]

Author(s):

Bianca Maria Scicchitano*, Gabriella Dobrowolny, Gigliola Sica and Antonio Musaro*   Pages 356 - 369 ( 14 )

Abstract:


Muscle homeostasis is guaranteed by a delicate balance between synthesis and degradation of cell proteins and its alteration leads to muscle wasting and diseases.

In this review, we describe the major anabolic pathways that are involved in muscle growth and homeostasis and the proteolytic systems that are over-activated in muscle pathologies. Modulation of these pathways comprises an attractive target for drug intervention.

Keywords:

Muscle homeostasis, Muscle atrophy, Degradation of cell proteins, Muscle wasting, Anabolic pathways, Muscle pathologies.

Affiliation:

Istituto di Istologia e Embriologia, Universita Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Largo Francesco Vito 1-00168, Roma, Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Istituto di Istologia e Embriologia, Universita Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Largo Francesco Vito 1-00168, Roma, Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome

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