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Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Biomarkers in Pancreatic Cancer

[ Vol. 20 , Issue. 8 ]

Author(s):

Natalia A. Gablo, Vladimir Prochazka, Zdenek Kala, Ondrej Slaby and Igor Kiss*   Pages 569 - 580 ( 12 )

Abstract:


Pancreatic cancer (PaC) is one of the most lethal cancers, with an increasing global incidence rate. Unfavorable prognosis largely results from associated difficulties in early diagnosis and the absence of prognostic and predictive biomarkers that would enable an individualized therapeutic approach. In fact, PaC prognosis has not improved for years, even though much efforts and resources have been devoted to PaC research, and the multimodal management of PaC patients has been used in clinical practice. It is thus imperative to develop optimal biomarkers, which would increase diagnostic precision and improve the post-diagnostic management of PaC patients. Current trends in biomarker research envisage the unique opportunity of cell-free microRNAs (miRNAs) present in circulation to become a convenient, non-invasive tool for accurate diagnosis, prognosis and prediction of response to treatment. This review analyzes studies focused on cell-free miRNAs in PaC. The studies provide solid evidence that miRNAs are detectable in serum, blood plasma, saliva, urine, and stool, and that they present easy-to-acquire biomarkers with strong diagnostic, prognostic and predictive potential.

Keywords:

Cell-free microRNA, pancreatic cancer, diagnosis, prognosis, prediction, non-invasive biomarker.

Affiliation:

Central European Institute of Technology, Masaryk University, Brno, Department of Surgery, Institutions shared with the Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Department of Surgery, Institutions shared with the Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Central European Institute of Technology, Masaryk University, Brno, Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno



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