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Single-cell RNA Sequencing: In-depth Decoding of Heart Biology and Cardiovascular Diseases

Author(s):

Zhongli Chen, Liang Wei, Firat Duru and Liang Chen*   Pages 1 - 17 ( 17 )

Abstract:


Background: The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniques have taken the lead in uncovering a new realm of cell types and molecular programs driving physiological and pathological processes in various organs and diseases. In particular, the emerging technique single-cell RNA sequencing dominates a breakthrough in decoding the cell heterogeneity, phenotype transition, and developmental dynamics in cardiovascular science.

Conclusion: Herein, we review recent advances in single cellular studies of cardiovascular system and summarize new insights provided by single-cell RNA sequencing in heart developmental sciences, stem-cell researches as well as normal or disease-related working mechanisms.

Keywords:

singe-cell RNA sequencing, cardiovascular disease, cardiogenesis, stem cells, vascular system, heart transcriptome.

Affiliation:

Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, State Key Laboratory of Cardiovascular Disease, Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, University Heart Center Zurich, University Heart Center, Zurich, State Key Laboratory of Cardiovascular Disease, Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing



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