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Hypothetical Proteins as Predecessors of Long Non-coding RNAs

[ Vol. 21 , Issue. 7 ]

Author(s):

Girik Malik, Tanu Agarwal, Utkarsh Raj, Vijayaraghava Seshadri Sundararajan, Obul Reddy Bandapalli* and Prashanth Suravajhala*   Pages 531 - 535 ( 5 )

Abstract:


Hypothetical Proteins [HP] are the transcripts predicted to be expressed in an organism, but no evidence of it exists in gene banks. On the other hand, long non-coding RNAs [lncRNAs] are the transcripts that might be present in the 5’ UTR or intergenic regions of the genes whose lengths are above 200 bases. With the known unknown [KU] regions in the genomes rapidly existing in gene banks, there is a need to understand the role of open reading frames in the context of annotation. In this commentary, we emphasize that HPs could indeed be the predecessors of lncRNAs.

Keywords:

Hypothetical proteins, lncRNA, aptamers, annotation, functional genomics, transcripts.

Affiliation:

Bioclues.org, Kukatpally, Hyderabad, 500072, NIIT University, NH8, Delhi- Jaipur Highway, District Alwar, Neemrana, Rajasthan 301705, NIIT University, NH8, Delhi- Jaipur Highway, District Alwar, Neemrana, Rajasthan 301705, Bioclues.org, Kukatpally, Hyderabad, 500072, Hopp Children's Cancer Center [KiTZ], Heidelberg, Bioclues.org, Kukatpally, Hyderabad, 500072

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