Girik Malik, Tanu Agarwal, Utkarsh Raj, Vijayaraghava Seshadri Sundararajan, Obul Reddy Bandapalli and Prashanth Suravajhala* Pages 1 - 5 ( 5 )
Hypothetical Proteins [HP] are the transcripts predicted to be expressed in an organism but no evidence of it exists in gene banks. On the other hand, long non-coding RNAs [lncRNAs] are the transcripts that might be present in the 5’ UTR or intergenic regions of the genes whose length are above 200 bases. With the known unknown [KU] regions in the genomes rapidly existing in gene banks, there is a need to understand the role of open reading frames in context of annotation. In this commentary, we emphasize that HPs could indeed be the predecessors of lncRNAs.
Hypothetical Proteins, Long Non-coding RNAs, protein-protein interactions, genome, hypothetical proteins
Khoury College of Computer Sciences, Northeastern University, 360 Huntington Ave. Boston, Massachusetts 02115, NIIT University, NH8, Delhi- Jaipur Highway, District Alwar, Neemrana, Rajasthan 301705, NIIT University, NH8, Delhi- Jaipur Highway, District Alwar, Neemrana, Rajasthan 301705, Bioclues.org, Hopp Children's Cancer Center [KiTZ], Heidelberg, Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue circle, Jaipur 302021, RJ