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A brief review of circRNA biogenesis, detection and function

Author(s):

Ying Liang*, Niannian Liu, Le Yang, Jianjun Tang, Yinglong Wang* and Meng Mei  

Abstract:


Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments.

Keywords:

CircRNA, alternative splicing, miRNA sponge, complementary intron, biomarker, disease

Affiliation:

College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, College of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang, Department of Basic teaching, Jiangxi Business School, Nanchang



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