Kazuhiro Ishikawa, Hideshi Ishii, Toshiyuki Saito and Keiichi Ichimura Pages 477 - 480 ( 4 )
DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preserving genomic integrity, plays multiple roles in fundamental biological processes, including the regulation of the DNA damage response, cell cycle checkpoint control, DNA repair, apoptosis, transcriptional regulation, exonuclease activity, ribonucleotide synthesis and embryogenesis. This review examines work that provides significant insight into the molecular mechanisms of several individual cellular processes which might be beneficial for developing novel therapeutic approaches to cancerous diseases with genomic instability.
DNA damage, replication, checkpoint, cancer
Jichi Medical University School of Medicine, Tochigi 329-0498, Japan.