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Myocardial Ischemia and Reperfusion Injury: Studies Using Transgenic and Knockout Mice

[ Vol. 6 , Issue. 6 ]

Author(s):

W. M.C. Jong, H. T. Cate, P. H. Reitsma and R. J. de Winter   Pages 449 - 460 ( 12 )

Abstract:


Transgenic and knockout mice are created and used for a large variety of research objectives. This overview describes the (genetically modified) mouse models that have been used to study the development of myocardial ischemia and reperfusion injury. The role of cytokines, chemokines, leukocytes, reactive oxygen species, anti-oxidants, NO, complement system, coagulation system, heat shock proteins, apoptosis and necrosis, and acute phase reactants are presented.

Keywords:

Myocardial, ischemia, reperfusion, mice, inflammation, overexpression, knockout, transgene

Affiliation:

Department of Cell Biologyand Genetics, Erasmus MC, Ee734, POB 1738, 3000 DR, The Netherlands.



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