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Microarray-Based Gene Expression Analysis of Hepatocellular Carcinoma

[ Vol. 11 , Issue. 4 ]

Author(s):

Thorsten Maass, Ioannis Sfakianakis, Frank Staib, Markus Krupp, Peter R. Galle and Andreas Teufel   Pages 261 - 268 ( 8 )

Abstract:


Microarray studies have successfully shed light on various aspects of the molecular mechanisms behind the development of hepatocellular carcinoma (HCC), such as the identification of novel molecular subgroups and the genetic profiles associated with metastasis and venous invasion. These experiments, mainly comprising genome wide profiling, potentially represent the basis of novel targeted therapeutic strategies in HCC. In response, we summarize the multiple reported expression profiles in HCC associated with HCC development, novel subgroups, venous invasion and metastasis.

Keywords:

HCC, systems biology, bioinformatics, oncogenomics

Affiliation:

Johannes Gutenberg University, Department of Medicine I, Building 301, Langenbeckstr. 1, 55101 Mainz, Germany.



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