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DNA Methylation and Bladder Cancer: Where Genotype does not Predict Phenotype

[ Vol. 21 , Issue. 1 ]


Amit Sharma, Heiko Reutter and Jörg Ellinger*   Pages 34 - 36 ( 3 )


Nearly three decades ago, the association between Bladder cancer (BC) and DNA methylation has initially been reported. Indeed, in the recent years, the mechanism connecting these two has gained deeper insights. Still, the mediocre performance of DNA methylation markers in the clinics raises the major concern. Strikingly, whether it is the inter-individual methylation variations or the paucity of knowledge about methylation fingerprints lying within histologically distinct subtypes of BC requires critical discussion. In the future, besides identifying the initial causative factors, it will be important to illustrate the cascade of events that determines the fraction of the genome to convey altered methylation patterns specific towards each cancer type.


Bladder cancer, DNA methylation, epigenetic, cancer biomarkers, genotype, phenotype.


Department of Ophthalmology, University Clinic Bonn, Bonn, Institute of Human Genetics, University Hospital of Bonn, Bonn, Department of Urology, University Hospital Bonn, Bonn

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