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Integrins and Cancer: Gene Expression, Epigenetics and Metastasis

[ Vol. 7 , Issue. 5 ]

Author(s):

T. Stuardi, S. M.O. Phipps and T. O. Tollefsbol   Pages 323 - 331 ( 9 )

Abstract:


Integrins are composed of a variety of binding subunits that are responsible for interacting with the extracellu-lar matrix and intracellular signaling pathways. Among their various functions, integrins have the ability to augment cellu-lar adhesion, influence cytoskeletal architecture, activate tyrosine kinase and affect cell survival. Many investigations have demonstrated a correlation between the regulation of integrin expression and tumor invasiveness and proliferation. Integrins affect transcription factors Twist and HoxD3, epigenetic regulation, matrix metalloproteinases, insulin-like growth factors, integrin-linked kinases and adherens junctions, which are all important components of tumorigenicity. Cancer cells modify their functional genomic composition thereby altering integrin expression. Understanding the rela-tionship between integrin expression and tumor activities could provide an important strategy for cancer treatment.

Keywords:

Integrin, cancer, Twist, ILK, MMP, epigenetic, HoxD3

Affiliation:

Department of Biology, 175 Campbell Hall, 1300 University Boulevard, Univeristy of Alabama at Bir-ingham, Birmingham, AL 35294-1170 USA.



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