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Evolutionary Perspective for Functional Divergence of Gene Family and Applications in Functional Genomics

[ Vol. 3 , Issue. 3 ]


Xun Gu, Yufeng Wang, Jianying Gu and Kent Vander Velden   Pages 201 - 211 ( 11 )


Gene family proliferation has provided the raw materials for functional innovations in many organisms. Although many models have been proposed on how duplicate genes have undergone functional divergence and survived in the long-term evolution, the details remain largely unknown. In this review paper, recent developments about this important issue have been discussed with special references to the implication for functional genomics. With a combination of large-scale genome sequencing and powerful computational analysis, we show that a great deal of functional information can be obtained from the evolutionary perspective, which can in turn be used to facilitate high throughput functional assays.


functional genomics, gene divergence, duplicate gene, gene sequence, functional divergence


Department of Zoology and Genetics, LHB Center for Bioinformatics and Biological Statistics, Iowa State University, 332 Science II Hall, Ames, IA 50011, USA

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