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Genetic Variation and Atherosclerosis

[ Vol. 9 , Issue. 1 ]


Erik Biros, Mirko Karan and Jonathan Golledge   Pages 29 - 42 ( 14 )


A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification. This review presents examples of present studies of the role of genetic polymorphism in atherosclerosis.


Atherosclerosis, genetic polymorphism, risk factors


Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University Townsville, QLD 4811, Australia.

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